Data Execution Protection and compromised machine

[jeffs at speakeasy.net (jeffs)]

To stop data execution protection in windows machines with it on by 
default (I notice this interferes with migrating processes although not 
with getting meterpreter installed and running) you can edit the 
boot.ini -- is this the standard way to turn this off so we can proceed 
further with the exploitation?

That does require a reboot and I'm wondering if there is another 
non-reboot method.