Rule Making Question

[EGD via Snort-sigs <snort-sigs () lists snort org>]

I am new to rule writing and wanted to know when using multiple "content" tags and "pcre" tags if they are conditional. 
In other words, do they trigger if all of them get found true or if at least one does.

i.e. content: "username"; content: "| 4c 55 6d|"; pcre "^[wW]hat[ .-]?[eE]ver$"

would the rule trigger is only one of the above examples is true or if all - bonus question, could I make it 
conditional within the rule?

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