Enterprise Microsoft / application patching solutions?

[Patrick A Hendrick <phendrick () gmail com>]

What do you guys and gals recommend for an enterprise patching solution 
for a company with around 250 servers and around 1000 workstations? This 
solution would really be beneficial if it was able to do both Microsoft 
OS patching and application patching. Obviously cost is a factor. Any 
suggestions besides WSUS would be great. Thank you in advance.